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In search of a perfect cure
It is easy to mistake him for a backpacker the straw hat, T-shirt,[link widoczny dla zalogowanych], sneakers and the bag strapped to his waist declare him to be a tourist. He recalls how his father and he, along with his brothers and sisters,[link widoczny dla zalogowanych], were diabetics. Born in Jamaica,[link widoczny dla zalogowanych], he fell victim to malaria at the age of 13.
Talking to The Hindu on his arrival here to attend a workshop on Open Source Drug Discovery organised by the National Institute for Interdisciplinary Science and Technology (NIIST), he recalled,[link widoczny dla zalogowanych], that time,[link widoczny dla zalogowanych], the malaria did not bother me. As a matter of fact, it kept me from going to school. I was intermittently well and feverish. In the middle of the day,[link widoczny dla zalogowanych], I would feel better and so go to play football. He is the first scientist to have synthesised the suspected toxin that causes cerebral malaria, a breakthrough that has the potential for the development of a vaccine against the dreaded disease.
Way back in 1966, at the University of Waterloo in Ontario,[link widoczny dla zalogowanych], he developed a process to make synthetic pheromones, the chemical attractants produced naturally by insects, paving the way for the development of a biological means of pest control. Another one of his research projects involved the role of oligosaccharides,[link widoczny dla zalogowanych], a complex sugar,[link widoczny dla zalogowanych], in immune responses and the role these molecules play in human diseases like malaria and AIDS.
It was in 1996,[link widoczny dla zalogowanych], he and his wife established the Natural Products and Glycotechnology (NPG) Research Institute at North Carolina State University in the US. support for working on sugar chemistry was always difficult he remembers. applications for funding were turned down time and again. But today the potential of carbohydrate chemistry is recognised
He however feels that the profit- driven pharmaceutical industry has failed to support research. figured I would be able to get support from the industry to work on diseases like malaria and TB that affect people in Third World countries. You cannot have the nation ravaged by malaria and TB and get stuck because you do not know who is going to pay for the vaccine and at the same time,[link widoczny dla zalogowanych], you have enough money to build roads
In India, he said,[link widoczny dla zalogowanych], you do not have to beg pharmaceutical companies because the CSIR is supporting drug development with Open Source Drug Discovery (OSDD),[link widoczny dla zalogowanych], a global initiative to provide affordable healthcare. Students in their late 40s and 50s are out of work because companies shed jobs as they grew in size
Asked about the prospects of developing drugs based on natural products for resistant strains,[link widoczny dla zalogowanych], he said,[link widoczny dla zalogowanych], these things take a long time. The bacterium does not want to die. It is always gong to try to outwit you and stay one step ahead
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